Steroid signaling activation and intracellular localization of sex steroid receptors
نویسندگان
چکیده
منابع مشابه
Receptors and Cell Signaling, Intracellular Receptors —steroid Hormones and No
Soluble extracellular molecules that cross the cell membrane, bind an intracellular receptor, and alter cellular function are essential regulators of mammalian endocrine biology. This article reviews two of the most well-studied and prototypical intracellular receptors: steroid hormone receptors, which are transcriptional regulators, and the nitric oxide receptor, which is soluble guanylate cyc...
متن کاملRapid signaling by steroid receptors.
Steroid receptors transcribe genes that lead to important biological processes, including normal organ development and function, tissue differentiation, and promotion of oncogenic transformation. These actions mainly result from nuclear steroid receptor action. However, for 50 years, it has been known that rapid effects of steroid hormones occur and could result from rapid signal transduction. ...
متن کاملSex steroid receptors in rheumatoid arthritis.
Rheumatoid arthritis (RA) is a disease characterized primarily by chronic inflammatory synovitis and is well-known to be associated with significant sex differences in its prevalence and clinical features. Sex steroids have been proposed to be involved in the pathogenesis of RA, but details pertaining to the expression of sex steroid receptors in RA synovial tissue have yet to be fully characte...
متن کاملSex steroid receptors in endometrial cancer.
Endometrial cancer contains estrogen and progestin receptor proteins. The receptor content inversely correlates with histologic differentiation. The correlation between receptor content and histologic subtype and stage of the disease may depend upon the degree of differentiation of the tumor. The status of the peritoneal cytology and depth of myometrial invasion by tumor do not correlate with t...
متن کاملRole of endocrine disrupting chemicals on the tissue levels of AhR and sex steroid receptors in breast tumours
Breast cancer affects Iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in Tehran. Thisstudy aimed to compare the AhR levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. Possible associations of AhR with lifestyle and reproductive risk factorsand ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2010
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-010-0103-1